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. 2018 Jul 20;23(7):1798.
doi: 10.3390/molecules23071798.

Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity

Zaibo Yang  1 , Pei Li  2 , Xiuhai Gan  3
Affiliations

Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity

Zaibo Yang et al. Molecules. .

Abstract

In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin. This study demonstrated that this series of novel pyrazole-hydrazone derivatives containing an isoxazole amide moiety could effectively control TMV.

Keywords: antiviral activity; isoxazole; pyrazole-hydrazone; tobacco mosaic virus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Synthetic route of the title compounds 6a–6r.
See this image and copyright information in PMC

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