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. 2018 Sep 6;379(10):979-981.
doi: 10.1056/NEJMc1807653. Epub 2018 Jul 24.

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception

Rebecca Zash  1 , Joseph Makhema  2 , Roger L Shapiro  3
Affiliations

Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception

Rebecca Zash et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Neural-Tube Defects in Infants According to Maternal ART Exposure Group and HIV Infection Status.
There were 7 additional infants with neural-tube defects in the full cohort: 3 born to women who started non-dolutegravir (DTG) antiretroviral therapy (ART) during pregnancy, 3 to human immunodeficiency virus (HIV)-infected women who did not receive ART during pregnancy, and 1 to a woman of unknown HIV infection status who did not receive ART. Among the women who had been receiving any non-DTG ART at conception, 5675 were receiving tenofovir-emtricitabine-efavirenz, 1446 tenofovir-emtricitabine-nevirapine, 2439 zidovudine-lamivudine-nevirapine, 452 tenofovir-emtricitabine-lopinavir-ritonavir, 312 zidovudine-lamivudine-lopinavir-ritonavir, 242 other specified ART regimens, and 734 unspecified non-DTG regimens. Among the women receiving DTG treatment that was started during pregnancy, the median gestational age at the initiation of ART was 19 weeks (interquartile range, 14 to 25), and there were 75 women who started ART at a gestational age of less than 6 weeks.
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References

    1. Zash R, Jacobson DL, Diseko M, et al. Comparative safety of dolutegravir-based or efavirenz-based antiretroviral treatment started during pregnancy in Botswana: an observational study. Lancet Glob Health 2018;6(7):e804–e810. - PMC - PubMed
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