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Comment
. 2018 Sep;8(9):1056.
doi: 10.1158/2159-8290.CD-NB2018-099. Epub 2018 Jul 23.

Roots of AML Detectable Long before Symptoms

No authors listed
Comment

Roots of AML Detectable Long before Symptoms

No authors listed. Cancer Discov. 2018 Sep.

Abstract

Using banked blood samples from large cohort studies, three independent groups have identified genetic signatures of acute myeloid leukemia in healthy individuals many years before cancer onset. The findings could lead to predictive blood testing and targeted drug treatment for preleukemic disease.

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  • Prediction of acute myeloid leukaemia risk in healthy individuals.
    Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI. Abelson S, et al. Nature. 2018 Jul;559(7714):400-404. doi: 10.1038/s41586-018-0317-6. Epub 2018 Jul 9. Nature. 2018. PMID: 29988082 Free PMC article.
  • Somatic mutations precede acute myeloid leukemia years before diagnosis.
    Desai P, Mencia-Trinchant N, Savenkov O, Simon MS, Cheang G, Lee S, Samuel M, Ritchie EK, Guzman ML, Ballman KV, Roboz GJ, Hassane DC. Desai P, et al. Nat Med. 2018 Jul;24(7):1015-1023. doi: 10.1038/s41591-018-0081-z. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988143 Free PMC article. Clinical Trial.

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