Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri^{1

2}, Zahra Kazemi^{3

4}, Jan Pencik^{1

3

5}, Ha T T Pham^{1

2}, Maximilian Kauer⁶, Rahil Noorizadeh^{1

2}, Barbara Sax¹, Harini Nivarthi^{1

7}, Michaela Schlederer^{1

3

5}, Barbara Maurer^{1

2}, Maximillian Hofbauer¹, Dave N T Aryee^{6

8}, Marc Wiedner^{1

7}, Eleni M Tomazou⁶, Malcolm Logan⁹, Christine Hartmann¹⁰, Jan P Tuckermann¹¹, Lukas Kenner^{1

3

5

12}, Mario Mikula^{3

13}, Helmut Dolznig^{3

13}, Aykut Üren¹⁴, Günther H Richter¹⁵, Florian Grebien¹, Heinrich Kovar^{6

8}, Richard Moriggl^{16

17

18}

Affiliations

¹ Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
² Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
³ Medical University of Vienna, Vienna, Austria.
⁴ Center of Physiology and Pharmacology, Vienna, Austria.
⁵ Clinical Institute of Pathology, Vienna, Austria.
⁶ Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
⁷ CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
⁸ Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
⁹ Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
¹⁰ Department of Bone and Skeletal Research, Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
¹¹ Institute of General Zoology and Endocrinology, University of Ulm, Ulm, Germany.
¹² University of Veterinary Medicine, Vienna, Austria.
¹³ Institute of Medical Genetics, Vienna, Austria.
¹⁴ Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, USA.
¹⁵ Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
¹⁶ Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.
¹⁷ Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.
¹⁸ Medical University of Vienna, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.

PMID: 30038364
PMCID: PMC6056495
DOI: 10.1038/s41419-018-0773-9

Published Erratum

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Tahereh Javaheri et al. Cell Death Dis. 2018.

. 2018 Jul 23;9(8):800.

doi: 10.1038/s41419-018-0773-9.

Authors

Affiliations

¹ Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
² Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
³ Medical University of Vienna, Vienna, Austria.
⁴ Center of Physiology and Pharmacology, Vienna, Austria.
⁵ Clinical Institute of Pathology, Vienna, Austria.
⁶ Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
⁷ CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
⁸ Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
⁹ Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
¹⁰ Department of Bone and Skeletal Research, Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
¹¹ Institute of General Zoology and Endocrinology, University of Ulm, Ulm, Germany.
¹² University of Veterinary Medicine, Vienna, Austria.
¹³ Institute of Medical Genetics, Vienna, Austria.
¹⁴ Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, USA.
¹⁵ Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
¹⁶ Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.
¹⁷ Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.
¹⁸ Medical University of Vienna, Vienna, Austria. richard.moriggl@lbicr.lbg.ac.at.

PMID: 30038364
PMCID: PMC6056495
DOI: 10.1038/s41419-018-0773-9

Abstract

Since publication of the article, the authors became aware that Figure 6(A,D) contained errors in the bands and loading controls. The newly compiled Figure 6A and 6D is given below.

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Figures

**Fig. 6**
Knockdown of Mcl1 or Cdk4-induced cell cycle arrest and inhibited ES cell proliferation. a Mcl1 and Cdk4 siRNA analysis and expression check in murine and human ES cell lines resulted in upregulation of total RB and lower amount of pS780-RB. b Colony-forming assay in Matrigel displayed reduced clonogenic potency of EF-dependent cell lines after knockdown of Mcl1 or Cdk4 by siRNA treatment. c Cell cycle analysis of Mcl1 or Cdk4 siRNA treatment displayed enhanced G1 arrest. d In vitro growth inhibition of mouse and human EF-dependent cell lines by Palbociclib as well as the combinatorial treatment of Palbociclib and Obatoclax in triplicate. Cells were treated with inhibitors at the indicated concentration for 24 h. e CDK4/6 inhibition by Palbociclib displayed similar results as seen in the CDK4 siRNA assay

See this image and copyright information in PMC

Erratum for

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.
Javaheri T, Kazemi Z, Pencik J, Pham HT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DN, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Üren A, Richter GH, Grebien F, Kovar H, Moriggl R. Javaheri T, et al. Cell Death Dis. 2016 Oct 13;7(10):e2419. doi: 10.1038/cddis.2016.268. Cell Death Dis. 2016. Retraction in: Cell Death Dis. 2019 Aug 13;10(8):605. doi: 10.1038/s41419-019-1853-1. PMID: 27735950 Free PMC article. Retracted.

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Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Affiliations

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Authors

Affiliations

Abstract

Figures

Erratum for

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