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Review
. 2018 Jul 23;7(3):19.
doi: 10.3390/ht7030019.

Venomics: A Mini-Review

David Wilson  1 , Norelle L Daly  2
Affiliations
Review

Venomics: A Mini-Review

David Wilson et al. High Throughput. .

Abstract

Venomics is the integration of proteomic, genomic and transcriptomic approaches to study venoms. Advances in these approaches have enabled increasingly more comprehensive analyses of venoms to be carried out, overcoming to some extent the limitations imposed by the complexity of the venoms and the small quantities that are often available. Advances in bioinformatics and high-throughput functional assay screening approaches have also had a significant impact on venomics. A combination of all these techniques is critical for enhancing our knowledge on the complexity of venoms and their potential therapeutic and agricultural applications. Here we highlight recent advances in these fields and their impact on venom analyses.

Keywords: bioinformatics; genomics; pharmacomics; proteomics; transcriptomics; venomics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Venom composition of an Australian funnel-web spider. Reversed-phase high-performance liquid chromatography (RP-HPLC) chromatogram of crude venom milked from Hadronyche infensa, highlighting the complexity of the venom. The sequences of three known peptides are shown. The sequences are catalogued in Arachnosever [16].
Figure 2
Figure 2
Schematic representation of the venomics pipeline in venom based therapeutic lead discovery.
See this image and copyright information in PMC

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