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. 1986 Jan;38(1):59-66.

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma

T P Dryja, J M Rapaport, J Epstein, A M Goorin, R Weichselbaum, A Koufos, W K Cavenee

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma

T P Dryja et al. Am J Hum Genet. 1986 Jan.

Abstract

We provide evidence that some human osteosarcomas arise subsequent to the development of homozygosity at loci on the long arm of chromosome 13. The resulting chromosome 13q homozygosity allows the phenotypic expression of any recessive allele on that chromosome. Clinical evidence suggests that it is the retinoblastoma locus within 13q14 that is involved in the formation of these bone tumors.

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References

    1. Nature. 1984 May 10-16;309(5964):174-6 - PubMed
    1. Nature. 1984 May 10-16;309(5964):172-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2447-51 - PubMed
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