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Review
. 2018 Sep;59(9):1350-1354.
doi: 10.2967/jnumed.117.190793. Epub 2018 Jul 24.

An Overview of PET Radiochemistry, Part 1: The Covalent Labels 18F, 11C, and 13N

Verena Pichler  1 , Neydher Berroterán-Infante  1 , Cecile Philippe  1 , Chrysoula Vraka  1 , Eva-Maria Klebermass  1 , Theresa Balber  1 , Sarah Pfaff  1 , Lukas Nics  1 , Markus Mitterhauser  1   2 , Wolfgang Wadsak  3   4
Affiliations
Free article
Review

An Overview of PET Radiochemistry, Part 1: The Covalent Labels 18F, 11C, and 13N

Verena Pichler et al. J Nucl Med. 2018 Sep.
Free article

Abstract

This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides 11C, 13N, and 18F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control.

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