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. 1986 Jan 14;134(1):279-84.
doi: 10.1016/0006-291x(86)90559-0.

ANF-like peptide(s) in the peripheral autonomic nervous system

W Debinski, J Gutkowska, O Kuchel, K Racz, N T Buu, M Cantin, J Genest

ANF-like peptide(s) in the peripheral autonomic nervous system

W Debinski et al. Biochem Biophys Res Commun. .

Abstract

The recent demonstration of the atrial natriuretic factor (ANF) within the brain has been extended in the present study by the additional localization of ANF-like activity in the peripheral nervous structures. Using a sensitive radioimmunoassay, it was possible to detect ANF-like immunoreactive peptide(s) in crude and chromatographically separated extracts of parasympathetic rat ganglia. The partially purified ANF-like peptide exhibited a biological action similar to cardiac ANF. This finding supports a possible involvement of ANF in the regulation of both, central and peripheral neuronal activities.

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