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. 2018;54(1):18.
doi: 10.1186/s41983-018-0019-x. Epub 2018 Jul 2.

Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin

Saher S Hashem  1 , Sadek M Helmy  1 , Nervana M El-Fayomy  1 , Mohammed I Oraby  2 , Mohammed Menshawy  1 , Nermin A Dawood  3 , Heba S Hashem  4
Affiliations

Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin

Saher S Hashem et al. Egypt J Neurol Psychiatr Neurosurg. 2018.

Abstract

Background: The early hours after an acute stroke are crucial; early accurate prediction of outcome in stroke patients can help health system providers and families to choose appropriate lines of management and plan for the future. The aim of this work is to assess the role of hemorheological parameters (such as blood viscosity, hematocrit, platelet aggregation, and leukocyte count), protein C, protein S, antithrombin III, and serum albumin as predictors of stroke outcome.

Methods: Thirty subjects, 20 patients with acute ischemic stroke within 24 h from the onset and 10 normal subjects, were included in this case control study. Clinical, functional, and radiological evaluation was done for the patients, and all patients and control were subjected to routine laboratory tests and assessment of blood viscosity, hematocrit level, platelet aggregation, protein C, protein S, and antithrombin III.

Results: Platelet aggregation was significantly higher and serum albumin was significantly lower in stroke patients compared to control (p value = 0.000 and 0.039) respectively. On comparing between patient with good and poor outcome, good outcome was associated with increased serum albumin level at admission (p value = 0.03) respectively. A significant negative correlation was found between total leukocyte count, hematocrit value, and stroke outcome (p value = 0.015 and 0.013) respectively. Only albumin was found to be a significant predictor for outcome by linear regression analysis.

Conclusion: Serum albumin, hematocrit level, and total leukocyte count at the time of presentation of ischemic stroke are useful markers for stroke outcome.

Keywords: Hemorheology; Natural anticoagulants; Serum albumin; Stroke outcome.

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Conflict of interest statement

A written informed consent was obtained from each participant in this study or from one of his family members, and the study was approved by the local ethical committee in Faculty of Medicine, Cairo University, in 28-9-2010.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Correlation between serum albumin and stroke outcome
See this image and copyright information in PMC

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