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. 2018 Jul 2;5(7):ofy158.
doi: 10.1093/ofid/ofy158. eCollection 2018 Jul.

In Vitro Activity of Ceftolozane/Tazobactam vs Nonfermenting, Gram-Negative Cystic Fibrosis Isolates

Jeanne B Forrester  1 , Lisa L Steed  2 , Barbara A Santevecchi  1 , Patrick Flume  2 , Gloria E Palmer-Long  2 , John A Bosso  1   2
Affiliations

In Vitro Activity of Ceftolozane/Tazobactam vs Nonfermenting, Gram-Negative Cystic Fibrosis Isolates

Jeanne B Forrester et al. Open Forum Infect Dis. .

Abstract

Ceftolozane/tazobactam (C/T) was tested and compared against 93 nonfermenting, Gram-negative clinical isolates from cystic fibrosis specimens. Based on current breakpoints for intra-abdominal and urinary tract infections (which may not be appropriate for pulmonary infections), C/T was found to be the most active agent against P. aeruginosa (95.7% susceptible), followed by piperacillin/tazobactam (89.4% susceptible). For other Gram-negative pathogens included, C/T had varying activity.

Keywords: Achromobacter species; Pseudomonas aeruginosa; Stenotrophomonas maltophilia; ceftolozane/tazobactam; cystic fibrosis.

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