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. 2018 Oct;146(14):1861-1869.
doi: 10.1017/S0950268818002017. Epub 2018 Jul 26.

Interactive effects of age and respiratory virus on severe lower respiratory infection

N Prasad  1 , A A Trenholme  2 , Q S Huang  1 , M G Thompson  3 , N Pierse  4 , M A Widdowson  3 , T Wood  1 , R Seeds  1 , S Taylor  2 , C C Grant  5 , E C Newbern  1 ; SHIVERS team
Affiliations

Interactive effects of age and respiratory virus on severe lower respiratory infection

N Prasad et al. Epidemiol Infect. 2018 Oct.

Abstract

We investigated risk factors for severe acute lower respiratory infections (ALRI) among hospitalised children 8 months were at greater risk from influenza-associated ICU admissions and long hospital stay. Children with ADV had increased LOS across all ages. In the first 2 years of life, the effects of different viruses on ALRI severity varies with age. Our findings help to identify specific ages that would most benefit from virus-specific interventions such as vaccines and antivirals.

Keywords: ADV adenovirus; ALRI acute lower respiratory infection; ICU intensive care unit admission; LOS hospital length of stay; RSV respiratory syncytial virus; children; respiratory virus; severe ALRI.

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Conflict of interest statement

None.

Figures

Fig. 1.
Fig. 1.
Study population selection among hospitalisations in children aged <2 years with an acute lower respiratory tract infection (ALRI), 2012−2015 winter seasons, Auckland, New Zealand.
Fig. 2.
Fig. 2.
Probability of ICU admission by age in months and RSV (A), influenza (B) positivity status among children aged <2 years hospitalised with acute lower respiratory infections, Auckland, New Zealand, 2012−2015.
Fig. 3.
Fig. 3.
Predicted length of hospital stay by age in months and influenza (A) or adenovirus (B) positivity status among children aged <2 years hospitalised with acute lower respiratory infections, Auckland, New Zealand, 2012−2015.
See this image and copyright information in PMC

References

    1. Nair H et al. (2013) Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. The Lancet 381, 1380–1390. - PMC - PubMed
    1. Nair H et al. (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. The Lancet 375, 1545–1555. - PMC - PubMed
    1. Sala KA et al. (2015) Factors associated with disease severity in children with bronchiolitis. Journal of Asthma 52, 268–272. - PubMed
    1. Pavia AT (2011) Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clinical Infectious Diseases 52, S284–S289. - PMC - PubMed
    1. Trenholme AA et al. (2017) Respiratory virus detection during hospitalisation for lower respiratory tract infection in children under 2 years in South Auckland, New Zealand. Journal of Paediatrics and Child Health 53, 551–555. - PubMed

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