The quest for mechanically and biologically functional soft biomaterials via soft network composites

Onur Bas¹, Isabelle Catelas², Elena M De-Juan-Pardo³, Dietmar W Hutmacher⁴

Affiliations

¹ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia.
² School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia; Department of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
³ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia.
⁴ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia; Institute for Advanced Study, Technische Universität München, 85748 Garching, Germany. Electronic address: dietmar.hutmacher@qut.edu.au.

PMID: 30048654
DOI: 10.1016/j.addr.2018.07.015

Review

The quest for mechanically and biologically functional soft biomaterials via soft network composites

Onur Bas et al. Adv Drug Deliv Rev. 2018 Jul.

. 2018 Jul:132:214-234.

doi: 10.1016/j.addr.2018.07.015. Epub 2018 Jul 24.

Authors

Onur Bas¹, Isabelle Catelas², Elena M De-Juan-Pardo³, Dietmar W Hutmacher⁴

Affiliations

¹ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia.
² School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia; Department of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
³ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia.
⁴ ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology (QUT), Kelvin Grove, Brisbane, QLD 4059, Australia; Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia; School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty (SEF), Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia; Institute for Advanced Study, Technische Universität München, 85748 Garching, Germany. Electronic address: dietmar.hutmacher@qut.edu.au.

PMID: 30048654
DOI: 10.1016/j.addr.2018.07.015

Abstract

Developing multifunctional soft biomaterials capable of addressing all the requirements of the complex tissue regeneration process is a multifaceted problem. In order to tackle the current challenges, recent research efforts are increasingly being directed towards biomimetic design concepts that can be translated into soft biomaterials via advanced manufacturing technologies. Among those, soft network composites consisting of a continuous hydrogel matrix and a reinforcing fibrous network closely resemble native soft biological materials in terms of design and composition as well as physicochemical properties. This article reviews soft network composite systems with a particular emphasis on the design, biomaterial and fabrication aspects within the context of soft tissue engineering and drug delivery applications.

Keywords: Composites; Fibre reinforcement; Fibrous networks; Functional tissue engineering; Hydrogels; Soft matrix composites.

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The quest for mechanically and biologically functional soft biomaterials via soft network composites

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The quest for mechanically and biologically functional soft biomaterials via soft network composites

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