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. 2019 Apr;7(4):1310-1313.e2.
doi: 10.1016/j.jaip.2018.07.008. Epub 2018 Jul 23.

Elevation in histamine and tryptase following exercise in patients with mastocytosis

Joseph M Kulinski  1 , Dean D Metcalfe  1 , Michael L Young  2 , Yun Bai  1 , Yuzhi Yin  1 , Robin Eisch  1 , Linda M Scott  1 , Hirsh D Komarow  3
Affiliations

Elevation in histamine and tryptase following exercise in patients with mastocytosis

Joseph M Kulinski et al. J Allergy Clin Immunol Pract. 2019 Apr.

Abstract

Patients with mastocytosis exhibit an increase in serum levels of mast cell-related mediators with exercise and therefore should be guided regarding management of mast cell-associated symptoms to improve safety and quality of life.

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Conflict of interest statement

Conflict of Interest statement

We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Figures

FIGURE 1.
FIGURE 1.
The effect of exercise on serum histamine and tryptase levels in patients with mastocytosis. A, Exercise challenge depicting blood draws (1 - 7). B, Mean ± SE change in serum histamine from baseline (time point 1) at time points 2 - 7. C, Baseline and peak post-exercise serum histamine levels (mean ± SE for each group). Same for tryptase (D,E). Data was derived from 3 technical replicate measurements at each time point. NV - Normal volunteer, CU - Cholinergic urticaria patient, ISM - Indolent systemic mastocytosis patient. A two-tailed Wilcoxon matched-pairs signed rank test was used to compare baseline and post-exercise peak levels of serum histamine (C) and tryptase (E) among individuals in the ISM patient cohort. **p=<0.01 *p=<0.05
See this image and copyright information in PMC

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