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Review
. 2019 Mar:123:110-114.
doi: 10.1016/j.nbd.2018.07.025. Epub 2018 Jul 23.

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa  1 , Vikesh Shrestha  2 , Nicholas Abend  3 , Denes Agoston  4 , Alicia Au  5 , Michael J Bell  6 , Thomas P Bleck  7 , Manuel Buitrago Blanco  2 , Jan Claassen  8 , Ramon Diaz-Arrastia  3 , Dominique Duncan  9 , Ben Ellingson  2 , Brandon Foreman  10 , Emily J Gilmore  11 , Lawrence Hirsch  11 , Martin Hunn  12 , Alaa Kamnaksh  4 , David McArthur  2 , Andrew Morokoff  13 , Terrence O'Brien  13 , Kristine O'Phelan  14 , Courtney L Robertson  15 , Eric Rosenthal  16 , Richard Staba  2 , Arthur Toga  9 , Frederick A Willyerd  17 , Lara Zimmermann  18 , Elisa Yam  2 , Susana Martinez  2 , Courtney Real  2 , Jerome Engel Jr  2
Affiliations
Review

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa et al. Neurobiol Dis. 2019 Mar.

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

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Figures

Figure 1:
Figure 1:
Outline of the entire course for the EpiBioS4Rx study
See this image and copyright information in PMC

References

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