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Comparative Study
. 1985 Dec 30;4(13B):3823-9.
doi: 10.1002/j.1460-2075.1985.tb04154.x.

Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level

M Mackay, M Goman, N Bone, J E Hyde, J Scaife, U Certa, H Stunnenberg, H Bujard
Comparative Study

Polymorphism of the precursor for the major surface antigens of Plasmodium falciparum merozoites: studies at the genetic level

M Mackay et al. EMBO J. .

Abstract

The gene for the precursor of Plasmodium falciparum merozoite surface antigens has been cloned. The entire sequence of the gene from a Thai isolate of the parasite is reported. It provides evidence for a signal peptide, a region containing short repeating peptides and an anchor sequence. In addition, the 5' end of a Papua New Guinea isolate has been sequenced. Comparison of these and other sequences defines, at the genetic level, a polymorphic region in the protein, and suggests that other parts of the protein are less susceptible to variation. Furthermore it appears that several signal peptides of P. falciparum exhibit extensive sequence homologies.

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References

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    1. J Exp Med. 1985 Jan 1;161(1):160-80 - PubMed
    1. Nucleic Acids Res. 1985 Jan 25;13(2):369-79 - PubMed
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