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Review
. 2018 Aug;20(8):868-877.
doi: 10.1038/s41556-018-0145-9. Epub 2018 Jul 26.

Metastatic niche functions and therapeutic opportunities

Toni Celià-Terrassa  1   2 , Yibin Kang  3
Affiliations
Review

Metastatic niche functions and therapeutic opportunities

Toni Celià-Terrassa et al. Nat Cell Biol. 2018 Aug.

Abstract

Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common functions of different metastatic niches: anchorage, survival support, protection from external insults, licensing proliferation and outgrowth. We highlight the emerging role of the metastatic niche in maintaining cancer stemness and promoting immune evasion, and discuss therapeutic opportunities against the metastatic niche.

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Comment in

  • Decoding cancer metastasis.
    [No authors listed] [No authors listed] Nat Cell Biol. 2018 Aug;20(8):859. doi: 10.1038/s41556-018-0167-3. Nat Cell Biol. 2018. PMID: 30050121 No abstract available.

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