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Review
. 2016 Jan 19:7:9-18.
doi: 10.2147/VMRR.S68905. eCollection 2016.

Infectious bursal disease virus in poultry: current status and future prospects

Tamiru Negash Alkie  1 , Silke Rautenschlein  2
Affiliations
Review

Infectious bursal disease virus in poultry: current status and future prospects

Tamiru Negash Alkie et al. Vet Med (Auckl). .

Abstract

Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.

Keywords: IBDV; epidemiology; immunity; poultry; vaccine.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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