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Comparative Study
. 1985 Dec;28(12):911-3.
doi: 10.1007/BF00703135.

Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects

T Awata, Y Shibasaki, H Hirai, T Okabe, Y Kanazawa, F Takaku
Comparative Study

Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects

T Awata et al. Diabetologia. 1985 Dec.

Abstract

A polymorphic locus flanking the 5' end of the insulin gene was studied in 154 unrelated Japanese diabetic and nondiabetic subjects. A predominance of the small allele was found with the following frequency: of 64 nondiabetic subjects, only 3 of 128 alleles were of the large class (2%); none of 78 alleles were of the large class in 39 Type 1 (insulin-dependent) diabetic subjects, and 4 of 102 alleles (4%) were of the large class in 51 Type 2 (non-insulin-dependent) diabetic subjects. The very low frequency of large allele may relate to the lower prevalence of atherosclerosis in Japanese. However, this possibility requires further examination.

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References

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