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. 2018 Jul 27;19(7):1999-2006.
doi: 10.22034/APJCP.2018.19.7.1999.

Dietary Inflammatory Index and Odds of Colorectal Cancer in a Case- Control Study from Iran

Nitin Shivappa  1   2   3 , James R Hébert, Susan E Steck, Akram Safari, Fatemeh Sedaghat, Bahram Rashidkhani
Affiliations

Dietary Inflammatory Index and Odds of Colorectal Cancer in a Case- Control Study from Iran

Nitin Shivappa et al. Asian Pac J Cancer Prev. .

Abstract

Background: In Iran, colorectal cancer (CRC) is the third and fourth leading cause of cancer incidence among men and women, respectively. Diet and inflammation have been suggested as important risk factors for CRC. We examined the association between dietary inflammatory index (DII) scores and CRC in a case-control study conducted in Iran. Methods: This study included 71 CRC cases and 142 controls hospitalized for acute non-neoplastic diseases. DII scores were computed from dietary intake assessed by a previously validated food frequency questionnaire. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) adjusted for age, sex, education, energy intake, exercise, body mass index (BMI), smoking, family history of cancer, and history of aspirin, acetaminophen, and multivitamin use. Results: Subjects with higher DII scores (i.e., indicating a more pro-inflammatory diet) had a higher odds of CRC with the DII being used as both a continuous variable (OR continuous = 2.20, 95% CI: 1.22-3.87) and as a categorical variable (OR tertile 3 vs tertile1 = 2.47, 95%CI: 1.10-5.55). Conclusion: These results indicate that a pro-inflammatory diet is associated with increased odds of CRC in this Iranian population.

Keywords: Dietary inflammatory index; colorectal cancer; case-control.

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Figures

Figure 1
Figure 1
Sequence of Steps in Creating the Dietary Inflammatory Index in the Iranian Colorectal Cancer Case-Control Study
See this image and copyright information in PMC

References

    1. Azizi F, Ghanbarian A, Momenan AA, et al. Prevention of non-communicable disease in a population in nutrition transition: Tehran lipid and glucose study phase II. Trial. 2009;10:5. - PMC - PubMed
    1. Baena R, Salinas P. Diet and colorectal cancer. Maturitas. 2015;80:258–64. - PubMed
    1. Barbaresko J, Koch M, Schulze MB, Nothlings U. Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review. Nutr Rev. 2013;71:511–27. - PubMed
    1. Bordoni A, Danesi F, Dardevet D, et al. Dairy products and inflammation: A review of the clinical evidence. Crit Rev Food Sci Nutr. 2017;57:2497–2525. - PubMed
    1. Chen Z, Wang PP, Woodrow J, et al. Dietary patterns and colorectal cancer: results from a Canadian population-based study. Nutr J. 2015;14:8. - PMC - PubMed