Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jul 26;174(3):503-504.
doi: 10.1016/j.cell.2018.07.018.

Whirling Platelets Away for Transfusion

Camelia Iancu-Rubin  1 , Ronald Hoffman  1 , Anna Rita Migliaccio  2
Affiliations
Comment

Whirling Platelets Away for Transfusion

Camelia Iancu-Rubin et al. Cell. .

Abstract

With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs.

PubMed Disclaimer

Comment on

  • Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
    Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K. Ito Y, et al. Cell. 2018 Jul 26;174(3):636-648.e18. doi: 10.1016/j.cell.2018.06.011. Epub 2018 Jul 12. Cell. 2018. PMID: 30017246

References

    1. Avanzi MP, and Mitchell WB (2014). Ex vivo production of platelets from stem cells. Br. J. Haematol. 165, 237–247. - PubMed
    1. Fong H, Mosoyan G, Patel A, Hoffman R, Tong J, and Iancu-Rubin C (2016). Preclinical Development of a Cryopreservable Megakaryocyte Cell Product from Cord Blood Derived Hematopoietic Stem Cells. Blood 128, 3859.
    1. Ito Y, Nakamura S, Tomohiro S, Naoshi S, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, et al. (2018). Turbulence activates platelet biogenesis to enable clinical scale manufacturing from human iPS cells. Cell 174, this issue, 636–648. - PubMed
    1. Kumar A, Mhaskar R, Grossman BJ, Kaufman RM, Tobian AA, Kleinman S, Gernsheimer T, Tinmouth AT, and Djulbegovic B; AABB Platelet Transfusion Guidelines Panel (2015). Platelet transfusion: a systematic review of the clinical evidence. Transfusion 55, 1116–1127, quiz 1115. - PubMed
    1. Lambert MP, Sullivan SK, Fuentes R, French DL, and Poncz M (2013). Challenges and promises for the development of donor-independent platelet transfusions. Blood 121, 3319–3324. - PMC - PubMed

LinkOut - more resources