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. 2018 Aug;41(8):491-493.
doi: 10.1016/j.tins.2018.05.010.

Exercise Your Kynurenines to Fight Depression

Francesca M Notarangelo  1 , Ana Pocivavsek  1 , Robert Schwarcz  2
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Exercise Your Kynurenines to Fight Depression

Francesca M Notarangelo et al. Trends Neurosci. 2018 Aug.

Abstract

Kynurenines, the major degradative products of the essential amino acid tryptophan, may play critical roles in the pathophysiology of depressive disorders. In 2014, Agudelo and colleagues reported that exercise indirectly modulates the metabolism of kynurenines in skeletal muscle, which in turn influences the brain and enhances resilience to depression.

Keywords: PGC-1α1; chronic mild stress; kynurenic acid; kynurenine; skeletal muscle.

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