Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct 8;13(10):1556-1557.
doi: 10.2215/CJN.03600318. Epub 2018 Jul 27.

Uromodulin and Nephron Mass

Edward Pivin  1 , Belen Ponte  2 , Sophie de Seigneux  2 , Daniel Ackermann  3 , Idris Guessous  4   5 , Georg Ehret  6   7 , Antoinette Pechère-Bertschi  8 , Eric Olinger  9 , Markus Mohaupt  3 , Bruno Vogt  3 , Pierre-Yves Martin  2 , Michel Burnier  1 , Murielle Bochud  4 , Olivier Devuyst  9 , Menno Pruijm  1
Affiliations

Uromodulin and Nephron Mass

Edward Pivin et al. Clin J Am Soc Nephrol. .
No abstract available

Keywords: Macrophage Activation Syndrome; Molecular Weight; Nephrectomy; Nephrons; Tamm-Horsfall; biomarker; birthweight; glomerular filtration rate; living kidney donation; tubule cells.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Urinary uromodulin increases with higher birth weight and decreases after nephrectomy. (A) Scatter plot and linear regression of birth weight and 24-hour urinary uromodulin excretion. (B) Box plot of urine uromodulin-to-creatinine ratio in 35 kidney donors before and after nephrectomy. Paired t test: *P<0.01; **P<0.03. 95% CI, 95% confidence interval.
See this image and copyright information in PMC

References

    1. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 307: 652–659, 1982 - PubMed
    1. Youhanna S, Weber J, Beaujean V, Glaudemans B, Sobek J, Devuyst O: Determination of uromodulin in human urine: Influence of storage and processing. Nephrol Dial Transplant 29: 136–145, 2014 - PubMed
    1. Pivin E, Ponte B, Pruijm M, Ackermann D, Guessous I, Ehret G, Liu YP, Drummen NE, Knapen MH, Pechere-Bertschi A, Paccaud F, Mohaupt M, Vermeer C, Staessen JA, Vogt B, Martin PY, Burnier M, Bochud M: Inactive matrix gla-protein is associated with arterial stiffness in an adult population-based study. Hypertension 66: 85–92, 2015 - PubMed
    1. Denic A, Mathew J, Lerman LO, Lieske JC, Larson JJ, Alexander MP, Poggio E, Glassock RJ, Rule AD: Single-nephron glomerular filtration rate in healthy adults. N Engl J Med 376: 2349–2357, 2017 - PMC - PubMed
    1. Garimella PS, Biggs ML, Katz R, Ix JH, Bennett MR, Devarajan P, Kestenbaum BR, Siscovick DS, Jensen MK, Shlipak MG, Chaves PH, Sarnak MJ: Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults. Kidney Int 88: 1126–1134, 2015 - PMC - PubMed

Publication types