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Review
. 2018 Sep;138(9):1911-1916.
doi: 10.1016/j.jid.2018.05.027. Epub 2018 Jul 26.

JAK Inhibitors for Treatment of Alopecia Areata

Eddy H C Wang  1 , Brigitte N Sallee  1 , Christina I Tejeda  2 , Angela M Christiano  3
Affiliations
Review

JAK Inhibitors for Treatment of Alopecia Areata

Eddy H C Wang et al. J Invest Dermatol. 2018 Sep.

Abstract

The advancement of genetic and preclinical studies has uncovered the mechanisms involved in the pathogenesis of alopecia areata (AA). The development of targeted therapies using small molecules blocking specific pathways for the treatment of AA is underway. By repurposing Food and Drug Administration-approved small molecule JAK inhibitors as treatments for AA, it has been demonstrated that JAK inhibitors can effectively reverse hair loss in patients with moderate to severe AA. In this review, we summarize and discuss the current preclinical and clinical studies on JAK inhibitors, as well as the prospects of using JAK inhibitors for the treatment of AA.

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Conflict of interest statement

Conflict on interest

AMC is a recipient of the research grant from Pfizer and Sanofi. She is also a consultant for Aclaris Therapeutics and Dermira. AMC is a shareholder of Aclaris Therapeutics.

EHCW, BNS, and CIT have no conflict of interest to disclose.

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