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Review
. 2019 Jan;105(1):49-52.
doi: 10.1002/cpt.1165. Epub 2018 Jul 29.

Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine

Laura B Ramsey  1   2   3 , Cynthia A Prows  4 , Kejian Zhang  5 , Shannon N Saldaña  6 , Michael T Sorter  3   7 , John P Pestian  3   8 , Richard J Wenstrup  9 , Alexander A Vinks  1   2   3 , Tracy A Glauser  3   10
Affiliations
Review

Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine

Laura B Ramsey et al. Clin Pharmacol Ther. 2019 Jan.
No abstract available

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Conflict of interest statement

Conflict of interest:

As an Associate Editor for Clinical Pharmacology & Therapeutics, Alexander A. Vinks was not involved in the review or decision process for this paper. The authors have no conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. Implementation steps for a new gene-drug pair.
GPS, Genetic Pharmacology Service. SOP, standard operating procedure. BPA, best practice alert.
Figure 2:
Figure 2:. Frequencies of CYP2D6 and CYP2C19 metabolizers tested with the Expanded Psychiatry Panel from September 2013 to June 2016.
Individual genes are shown at left and combinations of the two genes are shown at right. 6147 patients were tested, with 451 with a result of “Indeterminate” for either gene and 666 genotyping failures not shown. NM, normal metabolizer; PM, poor metabolizer; IM, intermediate metabolizer; UM, ultra-rapid metabolizer. The 20 CYP2D6 alleles tested: *2A, *3, *4, *5, *6, *7, *8, *9, *10, *11, *14, *15, *17, *18, *19, *20, *40, *41, *42, *44 and the long-range PCR is used for the duplication. There are 8 CYP2C19 alleles tested: *2, *3, *4, *5, *6, *7, *8, and *17. *1 is inferred by the absence of any of these alleles.
See this image and copyright information in PMC

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