Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Feb 11;14(3):1379-91.
doi: 10.1093/nar/14.3.1379.

Nucleotide sequence of the chicken 5-aminolevulinate synthase gene

D J Maguire, A R Day, I A Borthwick, G Srivastava, P L Wigley, B K May, W H Elliott
Free PMC article

Nucleotide sequence of the chicken 5-aminolevulinate synthase gene

D J Maguire et al. Nucleic Acids Res. .
Free PMC article

Abstract

5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken histone H2B gene and injected into the nuclei of Xenopus laevis oocytes.

PubMed Disclaimer

References

    1. Science. 1982 Jul 23;217(4557):316-24 - PubMed
    1. J Biol Chem. 1982 Jul 10;257(13):7887-97 - PubMed
    1. Eur J Biochem. 1983 Jan 1;129(3):615-20 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 May;80(9):2422-6 - PubMed
    1. Nucleic Acids Res. 1983 Apr 25;11(8):2447-64 - PubMed

Publication types

Substances

Associated data