Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul 27;19(8):2197.
doi: 10.3390/ijms19082197.

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

Shuang Liang  1 , Yaxuan Sun  2 , Xueling Dai  3
Affiliations
Review

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

Shuang Liang et al. Int J Mol Sci. .

Abstract

Chitooligosaccharide (COS), which is acknowledged for possessing multiple functions, is a kind of low-molecular-weight polymer prepared by degrading chitosan via enzymatic, chemical methods, etc. COS has comprehensive applications in various fields including food, agriculture, pharmacy, clinical therapy, and environmental industries. Besides having excellent properties such as biodegradability, biocompatibility, adsorptive abilities and non-toxicity like chitin and chitosan, COS has better solubility. In addition, COS has strong biological functions including anti-inflammatory, antitumor, immunomodulatory, neuroprotective effects, etc. The present paper has summarized the preparation methods, analytical techniques and biological functions to provide an overall understanding of the application of COS.

Keywords: COS analysis; COS biological activity; COS preparation; chitin; chitooligosaccharide (COS); chitosan.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of chitin (a); chitosan (b) and chitooligosaccharide (n ≤ 9, c).
Scheme 1
Scheme 1
Chitooligosaccharide preparation and analysis process.
Figure 2
Figure 2
The neuroprotective effect of COS against Alzheimer’s disease.
See this image and copyright information in PMC

References

    1. Rinaudo M. Chitin and chitosan: Properties and applications. Prog. Polym. Sci. 2006;31:603–632. doi: 10.1016/j.progpolymsci.2006.06.001. - DOI
    1. Senel S., Mcclure S.J. Potential applications of chitosan in veterinary medicine. Adv. Drug. Deliv. Rev. 2004;82:1467–1480. doi: 10.1016/j.addr.2004.02.007. - DOI - PubMed
    1. Li K., Xing R., Liu S., Li P. Advances in preparation, analysis and biological activities of single chitooligosaccharides. Carbohydr. Polym. 2016;139:178–190. doi: 10.1016/j.carbpol.2015.12.016. - DOI - PubMed
    1. Mekasha S., Byman I.R., Lynch C., Toupalová H., Anděra L., Næs T., Vaaje-Kolstad G., Eijsink V.G.H. Development of enzyme cocktails for complete saccharification of chitin using mono-component enzymes from Serratia marcescens. Process Biochem. 2017;56:132–138. doi: 10.1016/j.procbio.2017.02.021. - DOI
    1. Zou P., Yang X., Wang J., Li Y., Yu H., Zhang Y., Liu G. Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides. Food Chem. 2016;190:1174–1181. doi: 10.1016/j.foodchem.2015.06.076. - DOI - PubMed

LinkOut - more resources