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Editorial
. 2018 Jul 10:4:9.
doi: 10.1038/s41420-018-0076-z. eCollection 2018.

Modulation of liver steatosis by miR-21/PPAR α

Pedro M Rodrigues  1 , Cecília M P Rodrigues  1 , Rui E Castro  1
Affiliations
Editorial

Modulation of liver steatosis by miR-21/PPAR α

Pedro M Rodrigues et al. Cell Death Discov. .

Erratum in

No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Effects of liver miR-21 in NAFLD pathogenesis
During NASH, liver miR-21 is primarily expressed in inflammatory (and biliary) cells, contributing to overall cellular injury, inflammation and fibrosis, mostly through PPARα inhibition (left). Recent findings suggest that hepatocyte miR-21 also plays a role in development of steatosis, trough inhibition of PPARα-mediated lipid oxidation and fatty acid uptake, as well as through PPARα-independent modulation of genes involved in lipogenesis (right). ACOX2, Acyl-CoA Oxidase 2; CPT-1, Carnitine palmitoyltransferase I; Cyp4a14, cytochrome P450 4A14; FAT, fatty acid translocase; FOXA2, Forkhead box A2; FOXO1, Forkhead box O1
See this image and copyright information in PMC

References

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