Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep;21(3):197-207.
doi: 10.1007/s40477-018-0311-8. Epub 2018 Jul 30.

Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology

Rogier R Wildeboer  1 , Ruud J G van Sloun  2 , Arnoud W Postema  3 , Christophe K Mannaerts  3 , Maudy Gayet  4 , Harrie P Beerlage  4 , Hessel Wijkstra  2   3 , Massimo Mischi  2
Affiliations
Review

Accurate validation of ultrasound imaging of prostate cancer: a review of challenges in registration of imaging and histopathology

Rogier R Wildeboer et al. J Ultrasound. 2018 Sep.

Abstract
in English, Italian

As the development of modalities for prostate cancer (PCa) imaging advances, the challenge of accurate registration between images and histopathologic ground truth becomes more pressing. Localization of PCa, rather than detection, requires a pixel-to-pixel validation of imaging based on histopathology after radical prostatectomy. Such a registration procedure is challenging for ultrasound modalities; not only the deformations of the prostate after resection have to be taken into account, but also the deformation due to the employed transrectal probe and the mismatch in orientation between imaging planes and pathology slices. In this work, we review the latest techniques to facilitate accurate validation of PCa localization in ultrasound imaging studies and extrapolate a general strategy for implementation of a registration procedure.

Con lo sviluppo di nuove tecnologie di imaging per il cancro alla prostata, è diventata più pressante l'esigenza di una accurata registrazione e confronto tra le immagini e i reperti istopatologici. La localizzazione del tumore prostatico, oltre che il suo riconoscimento, richiede una validazione "pixel-topixel" dell'imaging basata sulla sua istopatologia ottenuta con la prostatectomia radicale. La tecnica di registrazione è cruciale per la metodica ecografica; devono essere tenute in conto non solo le deformazioni della prostata dopo resezione, ma anche la deformazione dovuta alla sonda transrettale impiegata e la possibile non corrispondenza tra i piani di orientamento impiegati nella formazione delle immagini e le sezioni istologiche. In questo lavoro gli Autori fanno una revisione delle recenti tecniche che facilitano la localizzazione del cancro della prostata in diagnostica ecografica ed estrapolano possibili strategie generali per implementare le procedure di registrazione degli esami.

Keywords: Diagnostic imaging; Histology; Prostate cancer; Review; Validation studies as topic.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

Rogier Wildeboer declares relationships with Philips.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
Three examples of 3D histopathology reconstructions from tumour-delineated macro-photos of the sliced radical prostatectomy specimen a–c. Volumetric lesions are colour-coded to depict their Gleason Score
Fig. 2
Fig. 2
Example of in vivo 3D reconstruction of the prostate based on a 2D US sweep: a schematic of the sweep procedure, b representation of manually segmented prostate in the ultrasound sweep video, and c resulting 3D reconstruction
Fig. 3
Fig. 3
Schematic of an example registration framework for the correlation of the US image with histopathology; (1) 3D reconstruction of the ex vivo radical prostatectomy specimen and in vivo gland (2) registration between in vivo and ex vivo model; (3) correlation of the pathology data and the contrast-enhanced recording; (4) pixel-wise superposition of the histopathologic data
See this image and copyright information in PMC

References

    1. American Cancer Society . Cancer facts & figures 2017. Atlanta: American Cancer Society; 2017.
    1. Mottet N, Bellmunt J, Bolla M, et al. EAU–ESTRO–SIOG Guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol. 2017;71:618–629. doi: 10.1016/j.eururo.2016.08.003. - DOI - PubMed
    1. Graif T, Loeb S, Roehl KA, Gashti SN, Griffin C, Yu X, Catalona WJ. Under diagnosis and over diagnosis of prostate cancer. J Urol. 2007;178:88–92. doi: 10.1016/j.juro.2007.03.017. - DOI - PubMed
    1. Loeb S, Vellekoop A, Ahmed HU, Catto J, Emberton M, Nam R, Rosario DJ, Scattoni V, Lotan Y. Systematic review of complications of prostate biopsy. Eur Urol. 2013;64:876–892. doi: 10.1016/j.eururo.2013.05.049. - DOI - PubMed
    1. Barret E, Durand M. Technical aspects of focal therapy in localized prostate cancer. Tech Asp Focal Ther Localized Prostate Cancer. 2015

LinkOut - more resources