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. 1986 Mar-Apr;26(2):210-3.
doi: 10.1046/j.1537-2995.1986.26286152919.x.

Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma

M A Wells, A E Wittek, J S Epstein, C Marcus-Sekura, S Daniel, D L Tankersley, M S Preston, G V Quinnan Jr

Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma

M A Wells et al. Transfusion. 1986 Mar-Apr.

Abstract

Because of concern about the safety of immune globulins prepared for injection, we studied the effects of ethanol fractionation of human plasma on human lymphotropic virus, type III, (HTLV-III) by spiking the products of various fractionation steps with HTLV-III. Tests of inactivation and removal indicated that the ratio of residual live virus in plasma fractions/live virus in starting plasma was about 1 X 10(-15) for precipitate II from which immune globulin for injection is manufactured. The results are reassuring regarding the potential safety of immune globulin.

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