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Comment
. 2018 Jul 31;9(4):e01417-18.
doi: 10.1128/mBio.01417-18.

New Tools for Syphilis Research

Sheila A Lukehart  1   2
Affiliations
Comment

New Tools for Syphilis Research

Sheila A Lukehart. mBio. .

Abstract

Syphilis research has been severely limited by the necessity to propagate Treponema pallidumin vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T. pallidum, the recent very convincing report of its successful long-term in vitro propagation opens numerous opportunities for development of genetic tools for studying pathogenesis and protein function, antigenic variation, and surface exposure of antigens. The possibility of more rapid isolation of new strains will expand our knowledge of this organism beyond the century-old Nichols strain.

Keywords: infectious disease; sexually transmitted diseases; syphilis.

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References

    1. Centers for Disease Control and Prevention 2017. Sexually transmitted disease surveillance 2016. Centers for Disease Control and Prevention, Atlanta, GA.
    1. Lukehart SA, Hook EW III, Baker-Zander SA, Collier AC, Critchlow CW, Handsfield HH. 1988. Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and therapy. Ann Intern Med 109:855–862. doi:10.7326/0003-4819-109-11-855. - DOI - PubMed
    1. Edmondson DG, Hu B, Norris SJ. 2018. Long-term in vitro culture of the syphilis spirochete Treponema pallidum subsp. pallidum. mBio 9:e01153-18. doi:10.1128/mBio.01153-18. - DOI - PMC - PubMed
    1. Fieldsteel AH, Cox DL, Moeckli RA. 1981. Cultivation of virulent Treponema pallidum in tissue culture. Infect Immun 32:908–915. - PMC - PubMed
    1. Fieldsteel AH, Cox DL, Moeckli RA. 1982. Further studies on replication of virulent Treponema pallidum in tissue cultures of Sf1Ep cells. Infect Immun 35:449–455. - PMC - PubMed

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