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Editorial
. 2018;14(9):1479-1480.
doi: 10.1080/15548627.2018.1483672. Epub 2018 Aug 1.

Finding a ribophagy receptor

Meiyan Jin  1 , Daniel J Klionsky  2
Affiliations
Editorial

Finding a ribophagy receptor

Meiyan Jin et al. Autophagy. 2018.

Abstract

Although ribophagy was demonstrated in budding yeast a decade ago, a specific receptor for this process has been unknown. Recently, a study revealed that NUFIP1 (nuclear FMR1 interacting protein 1) functions as a receptor for the selective degradation of ribosomes by starvation-induced autophagy in cultured mammalian cells. In addition to the identification of a selective autophagy receptor, this study suggests a strategy that can be adapted to the identification of additional novel receptor proteins.

Keywords: Autophagy; cargo; receptor; ribosomes; selective autophagy.

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Comment on

  • NUFIP1 is a ribosome receptor for starvation-induced ribophagy.
    Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM. Wyant GA, et al. Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26. Science. 2018. PMID: 29700228 Free PMC article.

References

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    1. Kraft C, Deplazes A, Sohrmann M, et al. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol. 2008;10:602–610. PubMed PMID: 18391941. - PubMed
    1. Wyant GA, Abu-Remaileh M, Frenkel EM, et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science. 2018;360:751–758. PubMed PMID: 29700228. - PMC - PubMed

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