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Review
. 2018 Jun 29:12:70-85.
doi: 10.2174/1874312901812010070. eCollection 2018.

Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review

Yan Deng  1   2 , Weifeng Zhu  2   3 , Xiaodong Zhou  2
Affiliations
Review

Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review

Yan Deng et al. Open Rheumatol J. .

Abstract

Behcet's disease (BD) is a chronic refractory multi-system autoimmune disorder that occurs in a genetically susceptible host. Multiple genetic factors have been identified that may contribute to the pathogenesis of BD. The major genes with polymorphisms associated with BD include HLA-B and -A, CIITA, ERAP1, MICA, IL10, IL12A, IL12RB2, IL23R, MEFV, IRF8, TNFAIP3, REL, TLR4, NOD1,2, CCR1,CCR3, GIMAP1,2,4, KLRC4, STAT4, NCOA5, FOXP3, PSORS1C1, FUT2, UBAC2, SUMO4, ADO-EGR2, CEBPB-PTPN1, and JPKL-CNTN5. These genes encode proteins involved mainly in immune regulation and inflammation, and some in transcription and post-translational modification. A complete view of these BD-associated genes may provide a clue to this complex disease in terms of its pathogenesis and exploring potentially targeted therapies for BD.

Keywords: Behcet's disease; CIITA; ERAPI; HLA; MICA; genetic association.

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