Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jul 5:2018:5187940.
doi: 10.1155/2018/5187940. eCollection 2018.

Clinical Applications of Adiponectin Measurements in Type 2 Diabetes Mellitus: Screening, Diagnosis, and Marker of Diabetes Control

Nabila A Abdella  1 , Olusegun A Mojiminiyi  2
Affiliations

Clinical Applications of Adiponectin Measurements in Type 2 Diabetes Mellitus: Screening, Diagnosis, and Marker of Diabetes Control

Nabila A Abdella et al. Dis Markers. .

Abstract

Background: Adipose tissue-derived adiponectin has pleiotropic protective effects with suppression of inflammatory and metabolic derangements that may result in insulin resistance, metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The aim of this study was to evaluate adiponectin as a diagnostic marker of T2DM and diabetes control.

Methods: Fasting adiponectin, insulin, glucose, and HbA1c were determined in 376 patients with known T2DM and 575 subjects with undiagnosed diabetes but with family history of T2DM. Clinical and anthropometric data were recorded. Subjects were classified on the basis of degree of adiposity, insulin resistance (IR), and achievement of target HbA1c levels. Receiver operating characteristic (ROC) curve analysis was used to examine the diagnostic performance for undiagnosed DM.

Results: In undiagnosed subjects, adiponectin was significantly lower in subjects with IR and diabetic subjects compared with those without. The area under the adiponectin ROC curve for diagnosis of DM was 0.740. In known T2DM subjects, those with good control had significantly higher adiponectin (8.6 versus 7.4 μg/mL) compared to subjects with poor control.

Conclusions: Adiponectin levels are associated with better glycemic control and could be a useful adjunct for screening for IR and T2DM. Therapeutic measures that increase adiponectin levels might be valuable targets for improving diabetes control and decreasing complications.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Adiponectin levels in subjects with undiagnosed diabetes grouped by homeostasis model assessment of insulin resistance. CI = confidence interval.
Figure 2
Figure 2
Receiver operating characteristic analysis of the usefulness of adiponectin for the diagnosis of type 2 diabetes mellitus.
See this image and copyright information in PMC

References

    1. Yang W. S., Lee W. J., Funahashi T., et al. Plasma adiponectin levels in overweight and obese Asians. Obesity Research. 2002;10(11):1104–1110. doi: 10.1038/oby.2002.150. - DOI - PubMed
    1. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of Clinical Investigation. 2006;116(7):1784–1792. doi: 10.1172/JCI29126. - DOI - PMC - PubMed
    1. Weyer C., Funahashi T., Tanaka S., et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. The Journal of Clinical Endocrinology and Metabolism. 2001;86(5):1930–5. doi: 10.1210/jcem.86.5.7463. - DOI - PubMed
    1. Ouchi N., Kihara S., Arita Y., et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 1999;100(25):2473–2476. doi: 10.1161/01.CIR.100.25.2473. - DOI - PubMed
    1. Stefan N., Vozarova B., Funahashi T., et al. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes. 2002;51(6):1884–1888. doi: 10.2337/diabetes.51.6.1884. - DOI - PubMed

Publication types

LinkOut - more resources