Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun 1;31(2):44-55.
doi: 10.1089/ped.2018.0886.

Asthma Endotyping and Biomarkers in Childhood Asthma

Amelia Licari  1 , Riccardo Castagnoli  1 , Ilaria Brambilla  1 , Alessia Marseglia  1 , Maria Angela Tosca  2 , Gian Luigi Marseglia  1 , Giorgio Ciprandi  3
Affiliations
Review

Asthma Endotyping and Biomarkers in Childhood Asthma

Amelia Licari et al. Pediatr Allergy Immunol Pulmonol. .

Abstract

Childhood asthma represents a heterogeneous challenging disease, in particular in its severe forms. The identification of different asthma phenotypes has stimulated research in underlying molecular mechanisms, such as the endotypes, and paved the way to the search for related specific biomarkers, which may guide diagnosis, management, and predict response to treatment. A limited number of biomarkers are currently available in clinical practice in the pediatric population, mostly reflecting type 2-high airway inflammation. The identification of biomarkers of childhood asthma is an active area of research that holds a potential great clinical utility and may represent a step forward toward tailored management and therapy: the so-called Precision Medicine. The aim of the present review is to provide an updated overview of asthma endotyping, mostly focusing on novel noninvasive biomarkers in childhood asthma.

Keywords: IgE; airway inflammation; asthma; biomarkers; children; eosinophils; exhaled nitric oxide.

PubMed Disclaimer

Conflict of interest statement

No competing financial interests exist.

Figures

<b>FIG. 1.</b>
FIG. 1.
Novel approach to phenotype and endotype childhood asthma.
See this image and copyright information in PMC

References

    1. Global Initiative for Asthma. GINA guidelines. Global strategy for Asthma Management and Prevention. Available at: www.ginasthma.org (accessed March1, 2018)
    1. Anderson HR, Gupta R, Kapetanakis V, Asher MI, Clayton T, Robertson CF, et al. . International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children. Int J Epidemiol 2008; 37:573–582 - PubMed
    1. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. . International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43:343–373 - PubMed
    1. Cowan K, Guilbert TW. Pediatric asthma phenotypes. Curr Opin Pediatr 2012; 24:344–351 - PubMed
    1. Reddy MB, Covar RA. Asthma phenotypes in childhood. Curr Opin Allergy Clin Immunol 2016; 16:127–134 - PubMed