Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug 2;15(8):e1002631.
doi: 10.1371/journal.pmed.1002631. eCollection 2018 Aug.

A collaborative translational research framework for evaluating and implementing the appropriate use of human genome sequencing to improve health

Affiliations

A collaborative translational research framework for evaluating and implementing the appropriate use of human genome sequencing to improve health

Muin J Khoury et al. PLoS Med. .

Erratum in

Abstract

In a Policy Forum, Muin Khoury and colleagues discuss research on the clinical application of genome sequencing data.

PubMed Disclaimer

Conflict of interest statement

I have read the journal's policy and the authors of this manuscript have the following competing interests: RCG receives compensation for consultation from AIA, Helix, Ohana, Prudential, and Veritas and is cofounder, advisor, and equity holder in Genome Medical, Inc. MFM reports personal fees from Invitae and grants from Regeneron, outside the submitted work.

References

    1. Collins FS. Shattuck lecture—medical and societal consequences of the Human Genome Project. N Engl J Med. 1999; 341: 28–37. 10.1056/NEJM199907013410106 - DOI - PubMed
    1. Biesecker LG, Green RC. Diagnostic clinical genome and exome sequencing. N Engl J Med. 2014; 370: 2418–2425. 10.1056/NEJMra1312543 - DOI - PubMed
    1. Moyer VA; U.S. Preventive Services Task Force. Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014; 160: 271–81. 10.7326/M13-2747 - DOI - PubMed
    1. Evans JP, Powell BC, Berg JS. Finding the Rare Pathogenic Variants in a Human Genome. JAMA. 2017; 317: 1904–1905. 10.1001/jama.2017.0432 - DOI - PubMed
    1. Lindor NM, Thiobodeau SN, Burke, W. Whole-Genome Sequencing in Healthy People. Mayo Clin Proc. 2017; 92: 159–172. 10.1016/j.mayocp.2016.10.019 - DOI - PubMed

LinkOut - more resources