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Review
. 2018 Jul 5:2018:1062562.
doi: 10.1155/2018/1062562. eCollection 2018.

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jinhuan Jiang  1 , Jiang Pi  1 , Jiye Cai  1   2
Affiliations
Review

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

Jinhuan Jiang et al. Bioinorg Chem Appl. .

Abstract

Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. In addition, zinc is well known to keep the structural integrity of insulin. So, ZnO NPs also have been effectively developed for antidiabetic treatment. Moreover, ZnO NPs show excellent luminescent properties and have turned them into one of the main candidates for bioimaging. Here, we summarize the synthesis and recent advances of ZnO NPs in the biomedical fields, which will be helpful for facilitating their future research progress and focusing on biomedical fields.

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Figures

Figure 1
Figure 1
The mechanism of ZnO NPs-induced toxicity in human liver cells [42]. Copyright 2012 Apoptosis.
Figure 2
Figure 2
Schematic illustration of antibacterial activity of ZnO NPs.
Figure 3
Figure 3
The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [121]. Copyright 2008 American Chemical Society.
See this image and copyright information in PMC

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