Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Aug 2;23(2):151-153.
doi: 10.1016/j.stem.2018.07.010.

Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis

Mark C Horowitz  1 , Steven M Tommasini  2
Affiliations
Free article
Comment

Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis

Mark C Horowitz et al. Cell Stem Cell. .
Free article

Abstract

PGC-1α is a transcriptional co-activator associated with PPARγ that regulates thermogenic gene expression in brown fat. In this issue, Yu et al. (2018) show that PGC-1α regulates marrow mesenchymal stromal cell lineage allocation in vivo, inhibiting marrow adipogenesis and associated bone loss in the aging skeleton and following ovariectomy-induced osteoporosis.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources