Resident Endothelial Progenitors Make Themselves at Home

Karen K Hirschi¹, Elisabetta Dejana²

Affiliations

¹ Departments of Medicine, Genetics, and Biomedical Engineering, Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: karen.hirschi@yale.edu.
² FIRC Institute of Molecular Oncology, Milan, Italy; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden. Electronic address: elisabetta.dejana@ifom.eu.

PMID: 30075124
DOI: 10.1016/j.stem.2018.07.014

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Resident Endothelial Progenitors Make Themselves at Home

Karen K Hirschi et al. Cell Stem Cell. 2018.

Free article

. 2018 Aug 2;23(2):153-155.

doi: 10.1016/j.stem.2018.07.014.

Authors

Karen K Hirschi¹, Elisabetta Dejana²

Affiliations

¹ Departments of Medicine, Genetics, and Biomedical Engineering, Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: karen.hirschi@yale.edu.
² FIRC Institute of Molecular Oncology, Milan, Italy; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden. Electronic address: elisabetta.dejana@ifom.eu.

PMID: 30075124
DOI: 10.1016/j.stem.2018.07.014

Abstract

Vascular endothelial cells adapt to their microenvironment and physiological demands to perform many essential functions. Recent studies (McDonald et al., 2018; Wakabayashi et al., 2018) suggest that quiescent endothelial stem/progenitor cells reside within blood vessels and are activated in response to injury, suggesting they can be harnessed for therapeutic applications.

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CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
Wakabayashi T, Naito H, Suehiro JI, Lin Y, Kawaji H, Iba T, Kouno T, Ishikawa-Kato S, Furuno M, Takara K, Muramatsu F, Weizhen J, Kidoya H, Ishihara K, Hayashizaki Y, Nishida K, Yoder MC, Takakura N. Wakabayashi T, et al. Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6. doi: 10.1016/j.stem.2018.01.010. Epub 2018 Feb 8. Cell Stem Cell. 2018. PMID: 29429943
Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities.
McDonald AI, Shirali AS, Aragón R, Ma F, Hernandez G, Vaughn DA, Mack JJ, Lim TY, Sunshine H, Zhao P, Kalinichenko V, Hai T, Pelegrini M, Ardehali R, Iruela-Arispe ML. McDonald AI, et al. Cell Stem Cell. 2018 Aug 2;23(2):210-225.e6. doi: 10.1016/j.stem.2018.07.011. Cell Stem Cell. 2018. PMID: 30075129 Free PMC article.

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Resident Endothelial Progenitors Make Themselves at Home

Affiliations

Resident Endothelial Progenitors Make Themselves at Home

Authors

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Abstract

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Medical