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Comment
. 2018 Sep;26(9):732-735.
doi: 10.1016/j.tim.2018.07.002. Epub 2018 Jul 31.

Direct In Vivo Microbial Transcriptomics During Infection

François-Olivier Hébert  1 , Brian Boyle  2 , Roger C Levesque  3
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Comment

Direct In Vivo Microbial Transcriptomics During Infection

François-Olivier Hébert et al. Trends Microbiol. 2018 Sep.

Abstract

The challenge in infectious diseases is monitoring infection in the host. Omics-based genomics and transcriptomics can define microbial genes expressed during infection and treatment with antimicrobials. Recent studies pinpoint a direct in situ in vivo approach revolutionizing infection monitoring and optimizing antimicrobial therapy using machine learning.

Keywords: Pseudomonas aeruginosa; in vitro comparisons; in vivo transcription; microbial infections.

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  • Pseudomonas aeruginosa transcriptome during human infection.
    Cornforth DM, Dees JL, Ibberson CB, Huse HK, Mathiesen IH, Kirketerp-Møller K, Wolcott RD, Rumbaugh KP, Bjarnsholt T, Whiteley M. Cornforth DM, et al. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5125-E5134. doi: 10.1073/pnas.1717525115. Epub 2018 May 14. Proc Natl Acad Sci U S A. 2018. PMID: 29760087 Free PMC article.

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