[Big data and artificial intelligence for diagnostic decision support in atypical dementia]

Abstract

The differential diagnosis of atypical dementia remains difficult. The use of positron emission tomography (PET) still represents the gold standard for imaging diagnostics. According to the current evidence, however, magnetic resonance imaging (MRI) is almost equal to fluorodeoxyglucose (FDG)-PET, but only when using new big data and machine learning methods. In cases of atypical dementia, especially in younger patients and for follow-up, MRI is preferable to computed tomography (CT). In the clinical routine, promising MRI procedures are e. g. the automated volumetry of anatomical 3D images, as well as a non-contrast-enhanced MRI perfusion method, called arterial spin labeling (ASL). Because of the rapidly growing amount of biomarker data, there is a need for computer-aided big data analyses and artificial intelligence. Based on fast analyses of the diverse and rapidly increasing amount of clinical, imaging, epidemiological, molecular genetic and economic data, new knowledge on the pathogenesis, prevention and treatment can be generated. Technical availability, homogenization of the underlying data and the availability of large reference data are the basis for the widespread establishment of promising analytical methods.

Keywords: Arterial spin labelling; Artificial intelligence; Machine learning; Positron emission tomography; Volumetry.