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Review
. 2018 Jul 20:6:80.
doi: 10.3389/fcell.2018.00080. eCollection 2018.

Mouse Yolk Sac Hematopoiesis

Toshiyuki Yamane  1
Affiliations
Review

Mouse Yolk Sac Hematopoiesis

Toshiyuki Yamane. Front Cell Dev Biol. .

Abstract

The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive erythroid cells are the most well-recognized cell lineages produced from this tissue. In addition to primitive erythroid cells, several types of hematopoietic cells are present, including multipotent hematopoietic progenitors. Yolk sac-derived blood cells constitute a transient wave of embryonic and fetal hematopoiesis. However, recent studies have demonstrated that some macrophage and B cell lineages derived from the early yolk sac may persist to adulthood. This review discusses the cellular basis of mouse yolk sac hematopoiesis and its contributions to embryonic and adult hematopoietic systems.

Keywords: B-1 B cell; blood cell development; embryonic hematopoiesis; fetal hematopoiesis; macrophage; yolk sac.

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Figures

Figure 1
Figure 1
A schematic representation of mouse development from stages E5.5 to E9.5.
Figure 2
Figure 2
Repopulation of lymphoid lineage cells by E9 yolk sac-derived cells. (A) Overview of the experimental procedure. (B) Representative flow cytometry plots showing T, B, and NK donor cell populations in the spleen at 3 weeks post-transplantation.
Figure 3
Figure 3
A model showing our current understanding of yolk sac hematopoiesis.
See this image and copyright information in PMC

References

    1. Ajami B., Bennett J. L., Krieger C., Tetzlaff W., Rossi F. M. (2007). Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10, 1538–1543. 10.1038/nn2014 - DOI - PubMed
    1. Al-Adhami M. A., Kunz Y. W. (1977). Ontogenesis of haematopoietic sites in Brachydanio rerio (Hamilton-buchanan) (teleostei). Dev. Growth Differ. 19, 171–179. - PubMed
    1. Al-Adhami M. A., Kunz Y. W. (1976). Haemopoietic centres in the developing angelfish, Pterophyllum scalare (Cuvier and Valenciennes). Wilehm Roux Arch. Dev. Biol. 179, 393–401. - PubMed
    1. Arora N., Wenzel P. L., McKinney-Freeman S. L., Ross S. J., Kim P. G., Chou S. S., et al. . (2014). Effect of developmental stage of HSC and recipient on transplant outcomes. Dev. Cell 29, 621–628. 10.1016/j.devcel.2014.04.013 - DOI - PMC - PubMed
    1. Bertrand J. Y., Jalil A., Klaine M., Jung S., Cumano A., Godin I. (2005). Three pathways to mature macrophages in the early mouse yolk sac. Blood 106, 3004–3011. 10.1182/blood-2005-02-0461 - DOI - PubMed

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