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Comment
. 2018 Oct;596(19):4555-4557.
doi: 10.1113/JP276673. Epub 2018 Aug 31.

Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression

Skyler Jackman  1 , Henrique von Gersdorff  1
Affiliations
Comment

Blocking slow exocytosis with slow Ca2+ buffers slows recovery from depression

Skyler Jackman et al. J Physiol. 2018 Oct.
No abstract available

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Figures

Figure 1
Figure 1. Two vesicle pools: fast and slow
A fast‐releasing pool of vesicles fuses quickly after depolarization and Ca2+ influx, while a larger pool of reluctant vesicles takes longer to release. Both pools can contribute to neurotransmitter release during a stimulus train. The fast‐releasing pool of vesicles recovers with a slow time constant, while the slow‐releasing pool recovers very quickly. Introducing the slow Ca2+ buffer EGTA into nerve terminals blocks the release of the fast‐replenishment pool, which appears to slow the recovery from synaptic depression. Caution is required when interpreting the Ca2+ dependence of recovery from depression.
See this image and copyright information in PMC

Comment on

  • Apparent calcium dependence of vesicle recruitment.
    Ritzau-Jost A, Jablonski L, Viotti J, Lipstein N, Eilers J, Hallermann S. Ritzau-Jost A, et al. J Physiol. 2018 Oct;596(19):4693-4707. doi: 10.1113/JP275911. Epub 2018 Aug 7. J Physiol. 2018. PMID: 29928766 Free PMC article.

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