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. 1986 Apr;320(6061):415-21.
doi: 10.1038/320415a0.

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

P Besmer, J E Murphy, P C George, F H Qiu, P J Bergold, L Lederman, H W Snyder Jr, D Brodeur, E E Zuckerman, W D Hardy

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

P Besmer et al. Nature. 1986 Apr.

Abstract

A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.

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