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. 2018 Nov:119:849-856.
doi: 10.1016/j.ijbiomac.2018.07.200. Epub 2018 Aug 3.

Cellulose‑copper as bio-supported recyclable catalyst for the clickable azide-alkyne [3 + 2] cycloaddition reaction in water

Lahoucine Bahsis  1 , Hicham Ben El Ayouchia  2 , Hafid Anane  2 , Karima Benhamou  3 , Hamid Kaddami  3 , Miguel Julve  4 , Salah-Eddine Stiriba  5
Affiliations

Cellulose‑copper as bio-supported recyclable catalyst for the clickable azide-alkyne [3 + 2] cycloaddition reaction in water

Lahoucine Bahsis et al. Int J Biol Macromol. 2018 Nov.

Abstract

Naturally-occurring cellulose has been employed as a bio-support macromolecule for the immobilization of either copper(I) or copper(II) ions in order to click azide and alkyne derivatives in water. Under such a click regime, 1,4-disubstitued-1,2,3-triazoles were obtained regioselectively in excellent yields at room temperature. The reaction work-up is simple and the bio-heterogeneous catalyst that has been fully characterized by AAS, SEM, EDX and FT-IR can be easily separated and reused at least five times without any significant decrease in its activity and selectivity, particularly in the case of the very stable CuI-Cellulose.

Keywords: 1,2,3-Triazole; Cellulose; Click chemistry; Copper ions; Water solvent; [3 + 2] cycloaddition.

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