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Meta-Analysis
. 2018 Aug 6;11(1):565.
doi: 10.1186/s13104-018-3670-5.

Diabetic nephropathy and hypertension in diabetes patients of sub-Saharan countries: a systematic review and meta-analysis

Fasil Wagnew  1 , Setegn Eshetie  2 , Getiye Dejenu Kibret  3 , Abriham Zegeye  3 , Getenet Dessie  3 , Henok Mulugeta  3 , Amanuel Alemu  4
Affiliations
Meta-Analysis

Diabetic nephropathy and hypertension in diabetes patients of sub-Saharan countries: a systematic review and meta-analysis

Fasil Wagnew et al. BMC Res Notes. .

Abstract

Objective: This meta-analysis was undertaken to estimate the prevalence of diabetic nephropathy and its association with hypertension in diabetics of sub-Saharan African countries.

Results: A total of 27 studies were included for the meta-analysis. The pooled overall prevalence of diabetic nephropathy was 35.3 (95% CI 27.46-43.14). In sub-group analyses by types of diabetes and regions, for instance, the prevalence was 41.4% (95% CI 32.2-50.58%) in type-2 diabetes mellitus and 29.7% (95% CI 14.3-45.1%) in Eastern Africa. Pooled point estimates from included studies revealed an increased risk of diabetic nephropathy with hypertension compared to without hypertension (OR = 1.67, 95% CI 1.31, 2.14). Diabetic nephropathy is a common complication in diabetic patients. Diabetic nephropathy complication is significantly higher in hypertensive patients. A preventive strategy should be adopted or planned to reduce diabetes mellitus and its complication of neuropathy, particularly in hypertensive.

Keywords: Diabetic nephropathy; Hypertension; Sub-Saharan countries.

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Figures

Fig. 1
Fig. 1
Pooled prevalence of DN among DM patients in sub-Saharan countries
Fig. 2
Fig. 2
Pooled odds ratio indicating the association of hypertension with DN in diabetic patients
See this image and copyright information in PMC

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