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. 2018 Sep 24;62(10):e01427-18.
doi: 10.1128/AAC.01427-18. Print 2018 Oct.

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

Kelley R Healey  1 , Milena Kordalewska  2 , Cristina Jiménez Ortigosa  2 , Ashutosh Singh  3 , Indira Berrío  4   5 , Anuradha Chowdhary  3 , David S Perlin  1
Affiliations

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

Kelley R Healey et al. Antimicrob Agents Chemother. .

Abstract

Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs were detected in Saccharomyces cerevisiae upon heterologous expression of C. aurisERG11 alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs. Similar to other Candida species, specific C. aurisERG11 mutations resulted directly in reduced azole susceptibility.

Keywords: Candida auris; ERG11; antifungal resistance; azoles; reduced azole susceptibility.

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References

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