Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Sep 24;62(10):e01261-18.
doi: 10.1128/AAC.01261-18. Print 2018 Oct.

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides

Sandrine Marchand  1   2   3 , Matthieu Boisson  4   2   5 , Shachi Mehta  2 , Christophe Adier  3 , Olivier Mimoz  4   2   6 , Nicolas Grégoire  4   2 , William Couet  4   2   3
Affiliations

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides

Sandrine Marchand et al. Antimicrob Agents Chemother. .

Abstract

Amikacin and gentamicin pharmacokinetic behaviors after nebulization were determined by comparing plasma and pulmonary epithelial lining fluid (ELF) concentrations in rats after intratracheal and intravenous administrations. ELF areas under concentration-time curve were 874 and 162 times higher after nebulization than after intravenous administration for amikacin and gentamicin, respectively. Even if both molecules appear to be good candidates for nebulization, these results demonstrate a much higher targeting advantage of nebulization for amikacin than for gentamicin.

Keywords: aminoglycosides; biopharmaceutics; nebulization.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Predicted concentration-time profiles of AMK, GEN, and TOB in plasma (solid line) and ELF (dashed line) from simultaneous plasma and ELF pharmacokinetic modeling, after i.v. administration (left panel) and intratracheal nebulization (right panel) of GEN (8 mg · kg−1), AMK (30 mg · kg−1), and TOB (3 mg · kg−1). Closed and open symbols represent experimental mean ± SD concentrations in plasma and ELF, respectively. TOB data obtained previously were reanalyzed using the same model as for AMK and GEN (3). TA, targeting advantage of NEB, corresponding to AUCELF after NEB over AUCELF after i.v. corrected for doses.
See this image and copyright information in PMC

References

    1. Sole-Lleonart C, Roberts JA, Chastre J, Poulakou G, Palmer LB, Blot S, Felton T, Bassetti M, Luyt CE, Pereira JM, Riera J, Welte T, Qiu H, Rouby JJ, Rello J, ESGCIP Investigators. 2016. Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines. Clin Microbiol Infect 22:359–364. doi: 10.1016/j.cmi.2015.12.016. - DOI - PubMed
    1. Gontijo AV, Brillault J, Gregoire N, Lamarche I, Gobin P, Couet W, Marchand S. 2014. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin. Antimicrob Agents Chemother 58:3942–3949. doi: 10.1128/AAC.02818-14. - DOI - PMC - PubMed
    1. Marchand S, Gregoire N, Brillault J, Lamarche I, Gobin P, Couet W. 2015. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 3. Tobramycin. Antimicrob Agents Chemother 59:6646–6647. doi: 10.1128/AAC.01647-15. - DOI - PMC - PubMed
    1. Gontijo AV, Gregoire N, Lamarche I, Gobin P, Couet W, Marchand S. 2014. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin. Antimicrob Agents Chemother 58:3950–3956. doi: 10.1128/AAC.02819-14. - DOI - PMC - PubMed
    1. Heller DN, Peggins JO, Nochetto CB, Smith ML, Chiesa OA, Moulton K. 2005. LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals. J Chromatogr B Analyt Technol Biomed Life Sci 821:22–30. doi: 10.1016/j.jchromb.2005.04.015. - DOI - PubMed

MeSH terms

LinkOut - more resources