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Review
. 2019 Sep 3;11(9):a035584.
doi: 10.1101/cshperspect.a035584.

Protein Synthesis and Translational Control: A Historical Perspective

Soroush Tahmasebi  1 , Nahum Sonenberg  1 , John W B Hershey  2 , Michael B Mathews  3
Affiliations
Review

Protein Synthesis and Translational Control: A Historical Perspective

Soroush Tahmasebi et al. Cold Spring Harb Perspect Biol. .

Abstract

Protein synthesis and its regulation are central to all known forms of life and impinge on biological arenas as varied as agriculture, biotechnology, and medicine. Otherwise known as translation and translational control, these processes have been investigated with increasing intensity since the middle of the 20th century, and in increasing depth with advances in molecular and cell biology. We review the origins of the field, focusing on the underlying concepts and early studies of the cellular machinery and mechanisms involved. We highlight key discoveries and events on a timeline, consider areas where current research has engendered new ideas, and conclude with some speculation on future directions for the field.

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Figures

Figure 1.
Figure 1.
Timeline of discoveries in the fields of protein synthesis (PS) and translational control (1951–2017). Principal advances are shown according to the year of publication, and are color coded by topic (color key and abbreviation definitions are at the end of the figure). Some other relevant events are also noted.
Figure 1.
Figure 1.
Timeline of discoveries in the fields of protein synthesis (PS) and translational control (1951–2017). Principal advances are shown according to the year of publication, and are color coded by topic (color key and abbreviation definitions are at the end of the figure). Some other relevant events are also noted.
Figure 1.
Figure 1.
Timeline of discoveries in the fields of protein synthesis (PS) and translational control (1951–2017). Principal advances are shown according to the year of publication, and are color coded by topic (color key and abbreviation definitions are at the end of the figure). Some other relevant events are also noted.
Figure 1.
Figure 1.
Timeline of discoveries in the fields of protein synthesis (PS) and translational control (1951–2017). Principal advances are shown according to the year of publication, and are color coded by topic (color key and abbreviation definitions are at the end of the figure). Some other relevant events are also noted.
Figure 1.
Figure 1.
Timeline of discoveries in the fields of protein synthesis (PS) and translational control (1951–2017). Principal advances are shown according to the year of publication, and are color coded by topic (color key and abbreviation definitions are at the end of the figure). Some other relevant events are also noted.
See this image and copyright information in PMC

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