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Comment
. 2019 Mar;24(3):322-327.
doi: 10.1038/s41380-018-0130-5. Epub 2018 Aug 6.

Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV

Siamak Nejad-Davarani  1 , Robert A Koeppe  1 , Roger L Albin  2   3   4 , Kirk A Frey  1   2 , Martijn L T M Müller  1   4 , Nicolaas I Bohnen  5   6   7   8
Affiliations
Comment

Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV

Siamak Nejad-Davarani et al. Mol Psychiatry. 2019 Mar.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors report no relevant biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
Time-activity curves for the delayed PET scan acquisition showing near identical white matter curves for the dementia with Lewy bodies (DLB) and elderly normal control (NC) groups. Time-activity curves for the thalamus and cortex show substantially lower activity values for the dementia patients compared to the control subjects.
Figure 2
Figure 2
Vesicular acetylcholine transporter [18F]FEOBV PET images show significantly reduced vesicular acetylcholine transporter activity in patients with dementia with Lewy bodies (upper row) compared to findings from representative elderly control subjects (lower row). Reductions are present not only in extensive cortical but also in limbic and sub-cortical regions, such as the thalami.
Figure 3
Figure 3
K1 flow delivery images (normalized to the cerebellum K1R) show prominent parieto-temporal, occipital and posterior cingulate cortical reductions in the patients with dementia with Lewy bodies (DLB, upper row) compared to findings from representative elderly control subjects (lower row). Frontal flow was relatively spared in the DLB patients.
See this image and copyright information in PMC

Comment on

References

    1. Kilbourn MR, Hockley B, Lee L, Sherman P, Quesada C, Frey KA, et al. Positron emission tomography imaging of (2R,3R)-5-[(18)F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter. Nucl Med Biol. 2009;36(5):489–493. - PMC - PubMed
    1. Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, et al. Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV. Mol Psychiatry. 2017;22(11):1531–1538. - PubMed
    1. Petrou M, Frey KA, Kilbourn MR, Scott PJ, Raffel DM, Bohnen NI, et al. In vivo imaging of human cholinergic nerve terminals with (−)-5-(18)F-fluoroethoxybenzovesamicol: biodistribution, dosimetry, and tracer kinetic analyses. J Nucl Med. 2014;55(3):396–404. - PubMed
    1. Schafer MK, Eiden LE, Weihe E. Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. I. Central nervous system. Neuroscience. 1998;84(2):331–359. - PubMed
    1. Gilman S, Koeppe RA, Nan B, Wang CN, Wang X, Junck L, et al. Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromes. Neurology. 2010;74(18):1416–1423. - PMC - PubMed

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