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. 2018 Jul 23:9:979.
doi: 10.3389/fphys.2018.00979. eCollection 2018.

Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

Wen-Zhong Xie  1 , Ying-Hui Jin  2 , Wei-Dong Leng  3 , Xing-Huan Wang  2   4 , Xian-Tao Zeng  1   2   3   4 ; BPSC investigators
Affiliations

Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

Wen-Zhong Xie et al. Front Physiol. .

Abstract

Objective: It has been reported that the periodontal disease is linked to a number of malignant tumors such as lung cancer and pancreatic cancer. In this study, we aimed to investigate the association of periodontal disease with risk of bladder cancer by a meta-analysis. Methods: PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI) were searched for eligible publications up to December 15, 2017. Cohort and nested case-control studies on the association between periodontal disease and risk of bladder cancer were included. After study selection and data extraction, pooled hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were calculated using a fixed-effect inverse-variance model. All analyses were performed using the RevMan 5.3 software. Results: Finally, five cohort studies were identified and included in this meta-analysis, involving 1,104 bladder cancer cases of 298,476 participants. Summary estimates based on adjusted data showed that periodontal disease was not significantly associated with the risk of bladder cancer (HR = 1.09, 95% CI = 0.95-1.25, I2 = 0%). A similar result was also observed after cumulative, subgroup and sensitivity analyses. Conclusions: Current evidence from cohort studies suggests that patients with periodontal disease may not be at an increased risk of developing bladder cancer.

Keywords: Periodontal diseases; cohort studies; meta-analysis; periodontitis; urinary bladder neoplasms.

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Figures

Figure 1
Figure 1
Study selection flow diagram.
Figure 2
Figure 2
Forest plot of periodontal disease and risk of bladder cancer in overall population.
See this image and copyright information in PMC

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